rkurtzjr: I had both the decipher and prolaris test. Decipher has a greater sample size. It measures genomic characteristics of the tumor and is independent of NCCN.org risks that doctors and patients look at.

The doctors do use this test to help determine potential aggressiveness and modes of treatment. My psa was 10.2 at age 69 but ended up with targeted narrow margin radiation with 5 treatments but no androgen therapy even though NCCN guidelines suggest it with a 10.2 psa. My last 3 blood tests had solid declining psa and I was treated in Jan/Feb 2023.

The Decipher test also helps to have another opinion outside your institution while at the same time giving one a little more confidence in the decisions one may make.

I also had the MyRisk hereditary cancer genetic test (Myriad Genetics), more for my children, daughter AND sons. If the test had shown a clinically significant result for a brca gene, then I would have alerted my daughter for potential breast cancer and so on ... for 50 tested genes.