What is the current position on the length of hormone treatment?

I had robotic prostatectomy 2006. GS6. Recurrence in 2016. HDT Lupron and Casodex for 6 years. Treatment holiday for 2 years beginning 2021 as PSA stayed low and body able to recover. PSA began to rise again and at PSA 3.7 started back on HDT. Side effects of flashes, fatigue, and aches kicking my butt as I am reacclimating to treatment again. So, hang in there, do all you can now to keep the number of enemy soldiers at bay for as long as you can, discouraging them from moving to bones etc., because then the war takes a different track.

Has anyone had ADT plus androgen inhibitors like Erleada and chemo like docetaxel, all at one time as a triple therapy. I saw a video by a Mayo urologist who recommended this as an attempt for a cure, for guys that are healthy enough to tolerate all these meds at one time. I would like to know how this sort of treatment worked, good and bad effects.

You are probably referring to Dr. Kwon at the Mayo clinic in Rochester.

I saw him in January 2017. He advocated triplet therapy - ADT, Chemotherapy, Radiation, based on my clinical history (see attached). He considered adding an ARI but given my response to the ADT (Lupron) and chemotherapy, he did not feel it was needed. Last Lupron shot was in May 18, so, about 4-1/2 years off treatment.

Back on now because of a single PLN identified in a Plarify scan, we did SBRT and are at the 9 of 12 months on ADT. Intent is to stop in April is PSA stays undetectable, go off treatment, and actively monitor again.

As to the SEs, well, you can read about those. Mine were the usual, fatigue, muscle and joint stiffness, hair loss, some toe and finger nail damage, metallic taste in my mouth. None really interfered completely with work, travel, exercise...

Kevin

Thanks Kevin. Indeed it was Dr Kwon. Your post was, as usual, very clear and helpful. During this journey, I had gotten confused about the triple therapy and the radiation instead of the Erleada inhibitor makes sense. I think that this triple treatment might be in my near future at UCLA. I wish that I had a Mayo Clinic and Dr Kwon here in LA but that is not my cancer center. Best of luck to you!

My hormone treatment was a total of 3 injections. Two Firmagon, one eligard, after which I received 5 sessions of high dose radiation. I rang the bell in May and am recovering well. The 3 I had were more than enough and don’t know if I could do a prolonged treatment with them. The side effects should be explained in greater detail, I wasn’t told of any, till I researched them after receiving them. The worst was the tiredness. I’m doing well now and time will tell. Just found out that brain fog is another side effect, which I experienced, nothing major but it was there.

I have been on ADT (Lupron) with Nubeqa for 15 months.
I had 6 rounds of chemo followed by almost 6 weeks of radiation. It is my understanding ADT would go on for 12-18 months after the end of radiation, as long as everything responds as expected.

I don’t think there is “a” consensus on length of time for hormone treatment. Each person is different. Best wishes and Happy New Year!

I'm 70, was GS7, Decipher High Risk, just finished 6 months of Orgovyx. This followed SBRT. After much research, speaking to almost countless RO, MO, etc., still feel confident in my treatment plan. I'll update you in 10 years I hope (-: Tx was at Mayo Jax.
Yes, there's no one standard. Takes alot of work to get to what you and your team feel comfortable about. Best wishes to all my brothers out there and happy new year!

The first time I had radiation treatment starting in early 2019, my local urologist told me to stay on ADT for 24 months. Since then, I’ve read studies that have shown 18 months is the sweet spot.

I had spot radiation earlier this year at the Mayo clinic, and Dr. Davis, my radiologist, told me I needed to do at least 12 months, but if I could handle it, to do 18 months of ADT. My personal opinion after researching and more recent conversations with better specialist is that 18 months is sufficient.

The sweet spot will be if you do not experience to occurrence.. I have finished 24months of ADT and am on 6 month holiday to see if PSA still is undetectable… everyone is different and our pathways are different …