I am 75 years old and was diagnosed three years ago with PCV and Jak 2 positive. Itching is sometimes unbearable. I take antihistamines morning and night which helps tremendously. I was put on Hydroxyurea for 2 weeks and after the first week started feeling great, no more fatigue or headaches. Itching was less severe but my platelets dropped from 337 to 57. Now off Hydroxyurea until blood draws in 2 weeks and adjust from there. I think one has to be patient and informed. It’s a balancing act that will have to be adjusted the rest of my life. Ask questions.