@stevm, I've now had 17 daily (M-F) treatments of radiation + capecitabine, with 11 more to go. I'm an outlier, in that I'm having a worse time with this than I did with FOLFIRINOX (8 cycles) -- ***but*** my capecitabine side effects are fairly mild.

I'm nauseated almost all the time despite alternating generic Zofran and generic Compazine -- that's the big problem, bc I can't do anything or even sit up in bed. Also, I'm very gassy; I have a little diarrhea (only on three days since 11-30-23); I have almost no appetite; and I've continued to lose weight since my Whipple (10-5-23).

I would cautiously say that I have less brain fog with capecitabine than FOLFIRINOX, but I'm not 100% sure. The variable is the anti-nausea med. I felt not-too-foggy from 11-30-23 thru about 12-12-23, when my secondary anti-emetic was generic Phenergan; after I switched to generic Compazine (c. 12-13-23), I felt a bit doped-up, but that's different from chemo brain-fog. (I'm reasonably good at detecting my level of fog bc I've worked mostly as a copy editor, meaning that I'm hyper-aware of how many typos I make, the types of typos I make, and the amt of time I need to digest a news article.)

Also: I'm not having any of the icky capecitabine side effects -- no mouth sores, no hand-foot disorder. So you can probably assume that you'll have an easier time with radiation + capecitabine than you did with FOLFIRINOX. Just be sure to moisturize the affected area twice daily with Eucerin or something similar (but not within the hour before treatment).