Improve bone density and strength without medication?

Posted by plav @plav, Dec 20, 2023

Any luck improving bone density and strength without medication? It seems the medications only mildly help ... and they only help some patients; some studies show the slight improvement in density does not mean quality bone was built. I'm not comfortable with moving forward with the treatments just because "that's what we give patients with osteoporosis". There seems to be no room for education or discussion, or research into actual results or other options.

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@lynn59

Hi Teb, you and I have had the conversation about HRT before, and I found your comment about starting within 10 years of menopause interesting. I am turning 65 very soon and 17 years out of menopause. My doctor refuses to prescribe it to me, but I found a doctor who would. When I went to fill the prescription this week, the pharmacist said take a pause until after the new year and do more research!! My prescription is for Climara 25 (0.025 mg/24hr patch weekly) and Prometrium (100 mg capsule) daily for 25 days per month. I’m Canadian so I’m not sure the drugs are the same in the US?

I’m in a holding pattern as I can’t get in to see an endocrinologist until May 2024 so I thought this might stabilize me until I can start on a bone building drug. I’d love to hear people’s comments about someone my age and years out of menopause starting on a low dose estrogen patch!!!

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I just started Estrogen cream. 50% E2 and 50% E3 for total of up to 2 mg. daily. I currently take 50 mg. Micronized progesterone and may increase to 100 mg. I’m about to start Testosterone cream- up to 3 mg. daily. Then, I’ll try low dose Tymlos. Hoping hrt will hold density after Tymlos.

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@awfultruth

Gently, can you provide a reference for Vitamin D and K2 competing for a receptor site? I have never heard this nor have I been able to construct a search that returns any information indicating such an interaction.

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Vitamin E and Omega 3 use the same intestinal receptors. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643801/#:~:text=Vitamin%20E%20and%20K%20follow,vitamin%20D%20absorption%20in%20intestine.
If you are taking a low dose K2 there may be enough receptors left for D. It is easier to separate ingestion. If your multi contains both, they are probably low dose K2.
Just when you get everything settled you realize that availability is not absorption.
This link is a bit of a slug.
D3 has a half life of about 15 days. MK2- 4 < 24 hours MK7 3 days.
.

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I might choose Tymlos with the lumbar structure at risk. If you make that choice be sure and follow windyshore. She took the clicks in a graduating measure to allow her body time to adjust and avoid side effects.
Either is a good choice.
wishing you the best luck

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@sallyj2

I just started Estrogen cream. 50% E2 and 50% E3 for total of up to 2 mg. daily. I currently take 50 mg. Micronized progesterone and may increase to 100 mg. I’m about to start Testosterone cream- up to 3 mg. daily. Then, I’ll try low dose Tymlos. Hoping hrt will hold density after Tymlos.

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Oh wow that is quite different from my prescription if I’m reading it correctly. 2mg estrogen versus my .025 mg estrogen patch …. And 50 mg progesterone versus my 100 mg. I’ll have to research these doses to help explain the differences. Thanks so much. Do you mind sharing your age and years since menopause).

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@gently

Vitamin E and Omega 3 use the same intestinal receptors. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5643801/#:~:text=Vitamin%20E%20and%20K%20follow,vitamin%20D%20absorption%20in%20intestine.
If you are taking a low dose K2 there may be enough receptors left for D. It is easier to separate ingestion. If your multi contains both, they are probably low dose K2.
Just when you get everything settled you realize that availability is not absorption.
This link is a bit of a slug.
D3 has a half life of about 15 days. MK2- 4 < 24 hours MK7 3 days.
.

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Thanks for your quick reply and for the link. Per that paper you should also avoid vitamin E at the same meal as vitamin D and also phytosterols which would mean many plant foods often considered especially healthy. It certainly does make life more complicated! And at least in this paper they did not think they had a final answer on this. Also they suggested a rather low percentage of interference with vitamin D. It's amazing how many studies are done and how few definitive answers we have.

BTW, I take high dose vitamin K2 MK4 (15 mg) with vitamin D and my levels of D go up and down readily based on whether I'm taking D and K2 and the dosage level of the D. If I quit taking them I go back down over several months. I cannot keep above 30 ng/ml with sunshine alone. Of course my experience might not be true for the next person.

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@cpd54

My scores are like yours. But I haven’t had a fracture. I’ve had 3 doctors tell me not to take drugs, an orthopedic surgeon, a functional medicine doctor and my dentist. My planned course of action is for 2 years try to do everything possible to up my scores without meds. Then have another dexa and see. My daily supplements are recommended by my FMD. Calcium citrate or malate- 1000 mg daily( I take Osteo-K by NBI), D3 5000 IU (I was significantly low), a B complex, Magnesium 2:1 ratio to calcium (I take citrate and glycinate), Vit K2 (I’ve done a lot if research on this one. FMD said up to 45 mg. That’s MK4. There is also MK7 that I take every other day at 182 mcg.), Boron 3 mg, Copper .9mg, Zinc 15 mg , Manganese- 1.8-23 mg, selenium 55 mcg. A lot of these I get with my multi vitamin.
She also recommended yoga, fast walking, stomping and whole body vibration for exercise.
You will find TONS of info and opinions about osteoporosis when you start researching. To me, you do what s best for you based on your health and comfort. I’m not comfortable taking the drugs. I’ll reassess after my next Dexa. Also there are other tests, P1NP and CTX, you can do to determine the action of your bone building.
I would suggest reading Dr Keith McCormicks books as well as Vitamin K2 and the Calcium Paradox by Kate Rheaume-Bleue. Also I’ve just started watching Dr Doug Lucas on YouTube.
Good luck in your journey.

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When researching supplements for bone maintenance I found info on Berberine, which apparently works to layer in the new bone being formed. I don't know if it really helps but it is something I had not heard of before. Selenium is also recommended in some online forums, though it seems to be more associated with immune system and endocrine system function.

Trace minerals and micronutrients are probably best taken in the correct foods but I guess it does not hurt to find reputable supplements.

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@awfultruth

Thanks for your quick reply and for the link. Per that paper you should also avoid vitamin E at the same meal as vitamin D and also phytosterols which would mean many plant foods often considered especially healthy. It certainly does make life more complicated! And at least in this paper they did not think they had a final answer on this. Also they suggested a rather low percentage of interference with vitamin D. It's amazing how many studies are done and how few definitive answers we have.

BTW, I take high dose vitamin K2 MK4 (15 mg) with vitamin D and my levels of D go up and down readily based on whether I'm taking D and K2 and the dosage level of the D. If I quit taking them I go back down over several months. I cannot keep above 30 ng/ml with sunshine alone. Of course my experience might not be true for the next person.

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Are you taking D3? MK2-4 more than once a day? 45mg is the "japanese" dose divided into 15mg doses. I''ve read 70 ng/ml is optimal for D. Why do you quit for several months?
The article isn't new, there have been subsequent (but where are they)
Yeah a lot of small studies and then disclaimers from the NIH.

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@mspatart

When researching supplements for bone maintenance I found info on Berberine, which apparently works to layer in the new bone being formed. I don't know if it really helps but it is something I had not heard of before. Selenium is also recommended in some online forums, though it seems to be more associated with immune system and endocrine system function.

Trace minerals and micronutrients are probably best taken in the correct foods but I guess it does not hurt to find reputable supplements.

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I’ll check the Berberine out. I do know selenium
Helps muscles but it can be toxic if you take to much.
Thanks for info

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@mspatart

When researching supplements for bone maintenance I found info on Berberine, which apparently works to layer in the new bone being formed. I don't know if it really helps but it is something I had not heard of before. Selenium is also recommended in some online forums, though it seems to be more associated with immune system and endocrine system function.

Trace minerals and micronutrients are probably best taken in the correct foods but I guess it does not hurt to find reputable supplements.

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I started taking Berberine; my M.D. said that was a good thing to take for osteoporosis. National Library of Medicine article stated: "Berberine has a long history of medicinal use to treat various diseases including bone disease in China. Recent studies have defined its function in promoting bone regeneration and great potential in developing new drugs. But the systemic mechanism of berberine on bone regeneration still needs more research to clarify."
Another article stated: "Berberine... Another supplement that is known to improve symptoms of osteoporosis is berberine; research suggests that berberine may lower osteoclast activity and boost osteoblast activity."

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@gently

Are you taking D3? MK2-4 more than once a day? 45mg is the "japanese" dose divided into 15mg doses. I''ve read 70 ng/ml is optimal for D. Why do you quit for several months?
The article isn't new, there have been subsequent (but where are they)
Yeah a lot of small studies and then disclaimers from the NIH.

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Hi Gently, I take D3 & MK2 4 mostly a couple of times a week. Never multiple times in a day. I have extreme food and chemical sensitivities and typically react to both D3 and K2. If my reactions are worse I take them less often. Sometimes I stop so that I won't be reacting to them and can try to figure out what else I'm reacting to. Sometimes I try to see if summer sun is enough to keep my D3 levels up (it never is). If my D goes down I try to get it back up. I'm shooting for the 50 ng/ml range based on a variety of "expert" opinions and guesses. Basically I have to experiment and ab lib my way around taking any supplements or foods for that matter. Which is probably why I have osteoporosis. I was on an extreme low calcium "diet" (unintentionally) for many many years. BTW, good researching on your part to find this info. I'd never heard of this in relation to D.

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