@dthomasc As you can see by those who have previously posted information, having peripheral neuropathy is very frustrating and we'd all like to find out the cause. I have axonal sensory motor both small and large fiber as diagnosed by Mayo in Rochester, now about 8 years since first getting a diagnosis by a local neurologist. I figured if Mayo can't give me the cause of my PN, then I have to stop searching and focus on, as Chris Trout says, quality of life and she is absolutely right. And that is what I've done for the past 4 years. I've discovered that with PN, being active as possible is important and try to implement a reasonable exercise program. Wish you the best and always remember, you are not alone. Ed