I was just diagnosed last month and my hematologist/oncologist explained that it is not uncommon for platelet levels to fluctuate. I was taking 500 mg twice a day every day and was just reduced to taking this 5 days a week. Regular blood tests are key to monitoring and adjusting dosing as needed - it is not unusual for platelet levels to fluctuate and I don't think anyone knows why they do. Good luck on your journey!