Hello. I often go to Mayo Clinic online when searching for information. I have 2 friends (husband and wife)are at Mayo. They check in with them every day. I discovered the discussion forum and wanted to see if others are having the same experiences as me and see if I can also offer up my experiences. You see, I am still having those same reactions with Rituximab after 6 treatment with it,even with the added pretreatments. The difference is I know exactly when they are coming on so I can get response dice meds into my system before the reactions escalate. My treatment yesterday went well as a result. I only had to interrupt the treatment for 2 15 minute intervals after the two reactions. I used to be wiped for 30 minutes to an hour after receiving the “antidote” meds before resuming treatment.