I am on the list for a Watchman. I am in chronic AFib, thanks to an overdose of thyroxine by a GP.

I have anemia, itching, rash, hives, flushing and a messed-up GI tract--all the result of two years of Eliquis. I also am chemically sensitive and have had trouble with various other groups of drugs, including thyroid medications and antibiotics.

I am not sure there are any guidelines, but my symptoms developed and became unbearable over time.