What is the recommended treatment after 6 Pluvicto doses?

Wanting to know what doctors are telling patients about what is course of action after first six pluvicto treatments?

Can Pluvicto be repeated?
Has it been in EU where it was approved longer ago?

Gina

Hi everyone,

My husband is stage 4 spread to bones and lymph nodes. After PSA rising we were referred for 6 treatments of Pluvicto and next week will be his 4th out of 6 treatments. Last appointment the PSA was up triggering scans. Scans now show small spot on the liver and small spot on the bladder. We aren’t sure whether to continue Pluvicto or abandon ship and go back to chemo.. or something else. So much pressure and so many decisions to be made. We are working with our doctor of course but also wanted to reach out for similar experiences, stories, outcomes, etc. from this group? Thank you in advance.

Just had 1st Pluvicto after 4 Chemo. Prayers and Hugs

@librarygirl, I'm glad that your husband's team is monitoring him closely. No one wants to continue treatment if it is not working. There are several discussions about Pluvicto in the support group. I think this one may be relevant for you:
- What is the recommended treatment after 6 Pluvicto doses?
https://connect.mayoclinic.org/discussion/what-is-the-recommended-treatment-after-6-pluvicto-doses/
I'm tagging fellow members @foamhand @rxharleydude @leebeth @robert570 @round5, who may have some experiences to add to this discussion.

So many decisions. I get how tough that is. Have you met with your husband's oncologist in the meantime?

@kbrz, how did your first Pluvicto treatment go?

Xofigo is a radiopharmaceutical similar to Pluvicto but is only effective against cancer in the bone and will not treat cancer in soft tissue or lymph nodes like Pluvicto does. I received four doses of Xofigo After which my doc pulled the plug as it was not doing me a whole lot of good so he started me on Docetaxol x 6 doses so that I could qualify to get Pluvicto (which currently requires treatment with chemotherapy first).

Better than any of my four Chemo treatments. I am nearing my three week blood work and Doctor meeting and will know more at that point. Non science, just how do I feel, I feel stronger daily and am back to the Gym and walking.
I was the first Pluvicto patient in my County and had representatives from all over in attendance. The process was less than thirty minutes and I drove myself home. Lots of hydration to clear your system and keeping safe distance from others per guidlines.
It went well.

Time is needed for bone marrow to recover after chemo and or Pluvicto. With regard to other treatments - I understand some doctors may recommend combing Docetaxel with Caroplatin instead of Pluvicto or as an alternative treatment. It also would depend on whether one is chemo healthy. What ever happened to cyber knife? Wouldn't that be another alternative.

I read that Radium 223 (Xofigo) works well for PC in the bones and that it should be used before receiving Pluvicto. It seems to me that many doctors want to use Pluvicto because it is so new. It also seems that there is a movement to get away from Chemo - maybe because some men are not chemo healthy or it is too debilitating.

Lastly, there is a clinical trial going on in South Carolina called the TAMARACK.

The Tamarack clinical trial uses a new generation of therapy, MGC018, which targets advanced prostate cancer. MGC018 is antibody-drug conjugate (ADC), which carries a chemotherapeutic drug and delivers the drug prostate cancer cells. This targeted approach to cancer treatment allows for higher drug concentrations with less damage to healthy tissue. The primary objective of this clinical trial is to see how MGC018 performs in patient with mCRPC

Hi I’m getting my first pluvicto treatment tomorrow any advice,how long did you have to stay away from people 2 days or 3 thanks Dave

@digger My husband's first treatment with Pluvicto was last week. Upon advice of the medical team, we used three days not sleeping in same bed or close contact and 7 days for no contact with children. Another tip -- RNs with the nuclear medicine team administering the treatment emphasized the importance of taking anti-nausea meds immediately after treatment to prevent symptoms (nausea, vomiting). He did that. His only side effect has been fatigue. Good luck on your treatment!