@tbb3512 welcome to Mayo Clinic Connect. You will find members and mentors here that have a variety of health conditions and experiences. It is a sharing and supportive community. I am unfamiliar with Spravato treatments. Hopefully someone has experience with this and can give you some input. What other antidepressants and treatments have you tried?

I’ve been on Spravato since the end of April. I’ve tried nearly every antidepressant there is. None worked very well at all. Spravato has worked for me. I don’t think about suicide at all. It’s given me more hope and motivation. Side effects aren’t too bad. It makes me feel high and tired on treatment days. I’ve also had some nausea on occasion at the higher dose. Your doctor can give you anti-nausea medication for this. Everyone reacts differently to Spravato. I definitely recommend giving it a try. It’s very inexpensive with most insurance. Also, ask about the observation rebate program.

Thank you so much. This is very helpful.

I have tried Spravato and had very positive experience for months and then it peaked out. My psych said that happens with some. She then pute on a new med Auvelity that if different than any other antidepressant in that it impacts same neurotransmitters that Spravato does. It's been about 1month and so far so good.

Hello all.
Thanks for including me in the discussion. I started Spravato treatments in 2019. I might be providing TMI, or as I like to think, I offer a different perspective.

At that time, the provider wasn't following the strict protocols. For example, a TV was on in the room. That provider discontinued treatments. Perhaps too many patients were going to the ER.

With my current provider,--of almost two years--we follow strict guidelines:
•I take medications to control my BP, anxiety, and nausea prior to treatment
•no cell phone or TV during treatment
•low watt blue/white lamp

About seven years ago, I had Gene Sight testing. SSRIs are in the red. Old-fashioned desipramine has worked much better.
Even with all the chemistry, I still remember that meds are only a component of my well-being. I see my psychiatrist every other week and therapist on alternate weeks. I've returned to teaching to use my brain as effectively as possible. With every psychiatrist I've seen, they've had their own strengths and philosophies. What I've learned about my brain is that it has the potential to heal itself and create new pathways. I know it's more complicated than that. However, I relate to, " if you don't use it, you lose it."
So, the mental stimulation and the social aspects are helping, too.

Am I perfect? No, never was, never will be...lol.

Am I better?

Yes.

Will I stay better?
One moment at a time.
Body, mind, and spirit.
☮️🎄
Good wellness, happy holidays, and Merry Christmas. Wishing all the best for all the right readons.

I have had ADHD, PTSD, and depression for as long as I can remember. I realized something was wrong but was unable to express it, or my parents were not paying attention. I suffered for years. I was diagnosed with ADHD four years ago and am currently on medication to treat it. This was a game changer for me. But the albatross continued to weigh heavily on me. I turned to IV Ketamine WITH Therapy. After six IV treatments, I moved to Spravato. K is much more expensive than Spravato, and I believe it is more effective. But Spravato is covered by insurance.

I read many people's descriptions of their ketamine journeys, and what I found missing from the majority of them was talk therapy. I cannot imagine taking this drug without someone to assist in handling any emotions that may emerge. Everyone's experience varies, yet it is human nature to seek connection. So, why not seek therapy? Medication can hide or even temporarily reduce symptoms, but if the underlying cause is not addressed, it will return in vengeful, unexpected ways.

IMHO, everyone should talk to someone. Some people are strolling about obvious and utterly self-unaware while they are suffering inside. You do not know everything, and neither does the bozo who left a Reddit comment offering you advice. Instead of going to a clinic that is "authorized by law" to give you the medication and then send you home to stew in your emotions without the support you need to help you make sense of it all, seek out professional care that also specializes in mental health.

My first spravato treatment was awesome. I felt lifted and I was in a good place. I had the second one, an increased dose, yesterday and I feel traumatized and hopeless. It was too much. I felt so sick afterward but felt like I needed to go because I had been basically dismissed. I couldn’t walk and was on the floor in the office apologizing for my state. I felt sick the rest of the night. Today I feel traumatized and so irritated and I want to give up. Tears in my eyes and I can’t focus. I live alone and haven’t seen anyone since nor can I get ahold of my dr office. I am supposed to go again on Monday and I seriously doubt I’m going. I feel worse than ever. So depressed and alone. Mak cause you don’t leave your appointments in an uber. If nobody cares enough to go with you like in my case just don’t go.

YOU ARE NOT ALONE! We are here for support and encouragement and even love for our fellow human beings who suffer.
I’m not a doctor so I can’t give you medical advice but I will say it sounds like that drug doesn’t agree with you. Especially at a higher dose. Maybe take a break then if you decide you want to try it again, stick with the lower dose. It’s your body and your mind and only you know what works for you. No one else. NAMI gives support to people like us and you could maybe find a peer to go with you. Not sure.
Know that I am thinking of you and offering up positive energy if you want it.

I have had depression and anxiety for years. It is now treatment resistant and my doctor has prescribed Spravato. I’m on Medicare . My secondary ,Champ Va ,does not cover it. ( although all the websights I’ve visited insists they do cover it.). I can’t afford it. Very discouraged and hopeless.

Hi. My brother went thru 8 spravato treatments and had no results. Not to say it won’t work for you. My friend who’s a therapist has a patient who had it and is doing well. My friend said you should follow up with therapy. Hoping things turn around.