@tinamarie10 - when was her transplant? Calcineurin Inhibitors (Tacrolimus, Cyclosporine) can cause pain. I was an extreme case. Got to where I couldn’t get out of a chair without help. You can search for CIPS (calcineurin inhibitor pain syndrome) online. Usually starts within a year of transplant, but goes away within 2 years. Tell her to hang in there!