@drumsace, I had a similar experience 5 years ago. I had two doctors look at my echo and instantly say HCM. It was textbook. Then a specialist decided it was not HCM and his response to "what should I look for then?" was (and I quote) "I dunno man." Those were my first, second and third opinions. Fast forward five years and guess what - a new echo, HCM diagnosis again. Then Camzyos which instantly made everything better. I feel awful for the folks who have not responded well on Camzyos - to have it hold such promise and then not work for them - it must be so discouraging. Best of luck with the next steps, whatever they may be.