I heard about the Nicotine patches recently from a pharmacist who specializes in functional medicine. I've started with 7 mg, gradually increasing the number of hours I'm wearing it. I can't do more than about 12 hours or I start feeling nauseous. Been using it almost 2 weeks now and I am noticing about 10% less pain, less anxiety, and better sleep (some days). I'm still very fatigued but I'll take the 10% improvement in other areas. Hopefully it will continue to improve.