← Return to Alpha-1 Antitrypsin Deficiency: Is it considered autoimmune?

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@radiya

@meq I have the same story! This thread has been so great to find. my daughter is ZZ, and my other daughter, myself, dad are MZ. His mom his severely COPD, assuming she is MZ, ZZ, or MM but her doctor got false negative and apparently doesnt understand genetics. I am running my own labs for EBV and for Lupus APLs bc I have plumetting oxygen, splitting fingers, rashes, chest pain when I get COVID-like infections 6 times now (not always testing positive). I suspect EBV or CMV reactivation. COVID has hit the kids and I hard. The medical system has truly failed my case, I am a clinician (acupuncture/herbs/functional med/nutrition) myself, so I keep researching figuring out my own case to survive. It manifests for me as no lung distress, just plumeting O2 sat. Wondering if others have experienced this too?

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Replies to "@meq I have the same story! This thread has been so great to find. my daughter..."

By a “false negative” do you mean MM? There is nothing false about that unless you have a sibling who is a ZZ she may have COPD for a different reason.

MM + MZ yields MM or MZ
The other parent of your daughters should be tested. They are either MZ or ZZ

What is your Alpha 1 level?Have you had a PFT? What is your FEV? What is your O2 level? Did you ever smoke?