Hello, I do not have ET but I do have PV which is the ugly sister of ET. PV is one of the MPNs. I became a member of the PV club in 2018. I originally took 500 mg of Hydroxyurea "Hydra" that is what my doctor calls it twice a day. My platelets are under control so now I am taking 500 mg only once a day in the morning. I have not noticed any difference. I have super fatigue around 7 pm every day. I eat dinner then hibernate like a bear all night. I plan all my brain-intensive activities in the morning. I go to a gymnasium 3 times a week and feel much better because of it. I volunteer a lot at my military veteran's clubs and stay active. Just turning 65 and plan to be around for a long time. I love to watch the bluegrass grow. Good luck to you from the heartland of America, Kentucky USA.