Hi @jewelfaux. The JAK2 mutation can be discovered/diagnosed with blood work. It isn’t necessary to have a bone marrow biopsy for confirmation. But because the mutation is associated with bone marrow disorders, sometimes a doctor will order further testing if they have questions about a patient’s condition.

Reading through some of your replies with other members, you’re concerned about the higher rate of HU you’re taking. If you’re not ‘feeling comfy’ with your current hematologists, it’s always your right to have a second opinion.
Are you seeing positive results with the reduction of platelets with the level of HU you’re taking? How about side effects?