1. < Neuropathy

Supplements

Posted by jerryw @jerryw, Nov 25, 2023

Hello everyone. Has anyone here ever tried any of these supplements like, " Nuphoria ", " Nerve Renew", or R- Alpha-Lipoic-Acid". Would like to see if someone has actual experience with them. Thank you.

Interested in more discussions like this? Go to the Neuropathy Support Group.

jfn | @jfn | Dec 3, 2023
In reply to @jerryw "Thanks for reply Jake. Sure are alot of caring people on here.. No complete diagnoses yet...." + (show)
@jerryw

Thanks for reply Jake. Sure are alot of caring people on here.. No complete diagnoses yet. I can't even get into Neurologist here in St Louis area until mid March. And I made that appointment back in first week of October. This world should be focusing on regenerating nerves than handing out meds that do not help. You know out of 40 million people with Neuropathat only about 1/3 is from Diabetic.
Most Neuropathy victims get it from poisoning pharmaceutical medications. And ofcourse many other items man has created. This comes from " Foundatifor Neuropathy " website, about Small Fiber Nerves and if they can regenerate.. "Yes, small nerve fibers are quite robust in their ability to regenerate. Moderate intensity aerobic exercise, followed by healthy diet (unsaturated over saturated fats) has been the two modalities most convincingly shown to slow or reverse SFN damage in human and animal subjects, respectively." If this is true than why aren't we focusing g more on this than just prescribing medications that do nothing. We are in a world of Pharmaceutical Dependance, and so many medications that can lead to neuropathy. I am going to call around to see about finding where I can get a skin biopsy done, that is a much more reliable test for Small Fiber Neuropathy.

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@jerryw
Hi,
I think that your question answer the question, about treatments for neuropathy. I have done many different things and for me diet, exercise, and massage (not for wimps), is working. I have great results with: cold laser therapy, Shockwave treatment, myofascial massage, diet. Yoga and exercise. I was an athlete in my youth and use all that I learned, to improve my neuropathy. I also have IVig. I did use supplements, my Bs counts became spectacular!

JFN

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jerryw | @jerryw | Dec 4, 2023
In reply to @johnbishop "Hi Jerry, Lots of different folks have shared what has helped them in many different discussions...." + (show)
@johnbishop

Hi Jerry, Lots of different folks have shared what has helped them in many different discussions. Although there really is no cure, there are lots of different treatments that have helped or provide relief for the symptoms. Here's the search results when searching for neuropathy success - https://connect.mayoclinic.org/search/discussions/?search=neuropathy+success

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Thanks John. Have you ever heard of people using a Spinal Cord/Back Stimulator? I was reading about these on government and few other websites about these having success with SFN and other neuropathies associated pains and sensory feelings. Thanks

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1 reply
crossette | @crossette | Dec 4, 2023
In reply to @jerryw "Can you qualify for Dissability with Neuropathy?" + (show)
@jerryw

Can you qualify for Dissability with Neuropathy?

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Yes. I met a guy who was in the process for diabetic neuropathy. And I was on disability for a couple years because of trauma caused N.

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crossette | @crossette | Dec 4, 2023

Because this forum thread is about Supplements I am posting this paragraph about Benfotamine which is a vitamin B1 related supplement. On page 1 or 2 of this thread someone said they found it effective for PN. This is available at any vitamin vendor in the USA without a prescription. (SwansonVitamins.com or Vitacost.com)

(from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8139599/ which reviews several other PN treatments)

Developed in late 1950s in Japan, benfotiamine is a synthetic lipid form of thiamin which is used as a treatment option for alcoholic neuropathy, sciatica, and other painful nerve disorders in alternative medicine. The mechanism for pain control is thought to be through increasing intracellular thiamine diphosphate levels, which serves as a cofactor of transketolase; this enzyme inhibits advanced glycation and lipid-oxidation end products, eventually preventing microvascular complications in diabetics [39].

A randomized pilot study was conducted to evaluate the efficacy of benfotiamine in patients with DPN. The study included 40 patients with type 1 and type 2 diabetes with two or more years of neuropathic symptoms. One group received 50 mg of benfotiamine four times daily, and another group received a placebo. The study lasted for three weeks. A neuropathy pain score was used to assess symptoms of polyneuropathy and vibration threshold was used as electrophysiological baseline parameter. The trial concluded a significant improvement in the neuropathic score in the benfotiamine treated group compared to the placebo group. However, no changes were reported in regards to improvements in vibration perception threshold [40]. A double-blind, placebo-controlled, phase-III-study including 165 patients with DPN were assigned to three groups, i.e., benfotiamine 600 mg daily, benfotiamine 300 mg daily and placebo. After six weeks of treatment, the neuropathic symptoms score showed improvement with benfotiamine compared to placebo with more improvement in higher dose group [41].

It is an economical and readily available product and could potentially serve as an adjuvant supplement for restoring normal physiological nerve function in diabetics. It may help with other chronic complications of diabetes due to its presumed mechanism of action.

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Mentor
John, Volunteer Mentor | @johnbishop | Dec 4, 2023
In reply to @jerryw "Thanks John. Have you ever heard of people using a Spinal Cord/Back Stimulator? I was reading..." + (show)
@jerryw

Thanks John. Have you ever heard of people using a Spinal Cord/Back Stimulator? I was reading about these on government and few other websites about these having success with SFN and other neuropathies associated pains and sensory feelings. Thanks

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Hi Jerry @jerryw, There are some discussions on using spinal cord stimulators for neuropathy if you want to learn what others have shared.

--- What's your experience: Boston Scientific Spinal Cord Simulator?: https://connect.mayoclinic.org/discussion/boston-scientific-spinal-cord-simulator/
--- Comparison of Spinal Cord Stimulators from Boston Sci., Nevro: https://connect.mayoclinic.org/discussion/comparison-of-spinal-cord-stimulators-from-boston-sci-nevro/

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1 reply
Sophie46 | @sophie46 | Dec 5, 2023

I take Alpha Lipoic Acid. At first it stopped the pain of peripheral neuropathy, but now the pain has returned. I now wear compression socks and the pain is less frequent and not as severe.

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jerryw | @jerryw | Dec 6, 2023
In reply to @casd57 "I've mentioned this elsewhere but I take these daily RN-ALA or just R-ALA 600mg B-1 Benfotiamine..." + (show)
@casd57

I've mentioned this elsewhere but I take these daily
RN-ALA or just R-ALA 600mg
B-1 Benfotiamine 300-600mg
B-6 Pyridoxal-5-Phosphate (NO HCL) 80-100mg
B-12 Methylcobalamin 1000-3000 mg
B-9 5-methyltetrahydrofolate 400mcg
L-Citrulline (nitric Oxide) 1000mg
Acetyl-L-Carntine 1000-3000mg
I take this handful split for AM and PM... it's like 10-12 pills each time(I haven't counted 🙂
Remember...with the pills
NO FILLERS like:
Magnesium Stearate
Gelatin
Maltodextrin
Dyes or Coloring
Titanium Dioxide
These fillers only make things worse...

I find that sugar and mainly chocolate trigger the pain...

I just went through this several times.... Just the other day I ate several Herisey Halloween-sized (mini) chocolate bars..and a couple of Reese Peanut butter cups... and the nerve pain that late-night early the next day was so intense..Yes, the pain doesn't start that hour it starts hours later..."Sugar Is A Blow Torch to Nerve Endings"
That I decided that I might finally break down and take meds... Now remember the above supplements are meant to heal the nerves which is a long process...(RECAP-My Nerve pain started last Dec-Jan, went to the Doc in Feb he offered Gabapin but I didn't like it and it didn't help with the intense pain I was having so he put me on pregabalin, I kept upping the dosage until it kind of worked but I was unsteady on my feet and with my job walking up to 10,000(5miles) steps a day I couldn't do it so I quit the meds and went on a search to find a solution which lead me to the above supplements RECAP done)
So back to sugar but mainly chocolate for me.... I ate the sweets... and I had pain like in the beginning ..brought tears (Yes I'm a Man) and I had to lay down...but the pain wouldn't go away totally so decided to pull out Pregabalin 75mg I still had..took two and within an hour the pain was all gone.. 12 hours later I could feel it starting up... So I've been taking 2- Pregabalin 75mg twice a day/every 12 hours and I've been pain-free..
So my thought is this....While my nerves are healing with the above supplements, I'll take Pregabalin also so that I can be more productive at home and work.
I know the above supplements work because my feet are better and I'm able to function well with short breaks but with the Pregabalin I'm hoping for even more productive days with fewer breaks but we will see...

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Hello casd57. What kind of neuropathy do you have? Small Fiber, Diabetic, etc.? Thanks Jerry

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casd57 | @casd57 | Dec 6, 2023

Not Diabetic...
Prerifal(sp?) Neuropathy is the only thing the Doctor said..
What I feel is my feet are on fire...I feel weakness up to my knees and I feel pain in my arms and hands but not even close to what I can feel in my feet..

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1 reply
jerryw | @jerryw | Dec 6, 2023
In reply to @casd57 "Not Diabetic... Prerifal(sp?) Neuropathy is the only thing the Doctor said.. What I feel is my..." + (show)
@casd57

Not Diabetic...
Prerifal(sp?) Neuropathy is the only thing the Doctor said..
What I feel is my feet are on fire...I feel weakness up to my knees and I feel pain in my arms and hands but not even close to what I can feel in my feet..

Jump to this post

Wow. I feel fire in my feet also. Also like they have plaster inside the bottom . And some burning in lower legs. Sometimes cramping in bottom of right foot. Do you still feel like they are making improvement with the supplements? Sounds like Small Fiber Neuropathy.

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1 reply
casd57 | @casd57 | Dec 6, 2023
In reply to @jerryw "Wow. I feel fire in my feet also. Also like they have plaster inside the bottom..." + (show)
@jerryw

Wow. I feel fire in my feet also. Also like they have plaster inside the bottom . And some burning in lower legs. Sometimes cramping in bottom of right foot. Do you still feel like they are making improvement with the supplements? Sounds like Small Fiber Neuropathy.

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Yes.... In Feb to July I made progress but I wasn't taking everything I listed above plus what I was taking was wrong... like just "ALA" not R-ALA or RN-ALA ....and was taking other stuff to help blood flow but it was full of fillers that I mentioned above so that made them less effective...
So like I said in the beginning I couldn't hardly mow my lawn before I had to go lay down and grit my teeth through the pain.... Now, we just went to Disney World-Epcot-Universal 11/14 and we walked 8- 10 miles a day with short sit downs... I also noticed the last few months my feet recovered very quickly...
So yes, they are so much better...

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