I've had ET-CALR for 15 years. I'm on 1,000mg 3xweek + 500mg the rest of the time. On that dose for last five years. Feeling OK, with the ups and down with fatigue and brain fog, skin/hair/nail changes (get a good moisturizer). Drinking 64 oz water every day + daily exercise and fresh air help. Just got out my old wool blanket so I can continue to sit on the porch for in afternoon to watch the birds at the feeder. Michigan winter has arrived! Watch your stress levels. I don't find that stress increases my platelets, but it is easier for me to get overwhelmed if I don't pace myself.