It is hard to evaluate progress of people because as you said every patient is different. I was diagnosed with Stage IV inoperable cancer in June of 2022. I started chemo in July of last year. My CA19-9 went from 450 to 8 to 20 (last one) and my tumor in the pancreas is now not seen on CT & lung (my area of metastasis) nodules are gone and some are stable. I was only on Gemczar & Abraxane & have had 41 chemo treatments thus far. I am 73. The worst problems I have had have been the peripheral neuropathy, especially to my feet & ankle area. Knowing a prognosis at the end of June 2022 was devastating to me since I was given 2-4 months without treatment and only 11 months with treatment! I happily informed the doctor in FL who gave me that prognosis that I was still alive when I went over my 11th month. I attribute a lot to those who included me in their prayers & to the doctor in GA & his team who treat me. It took me a long time to find this group. It was difficult to find survivors or anyone going through this cancer journey, but I am happy to have discovered this site. Hope this helps some. I am sure others will answer you.