Laminectomy a year ago immediately relieved pain in hips and legs that had rendered me almost unable to walk. But I have been left with (neuropathy) numbness and tingling in my feet, but so far not a lot of pain. The numbness does affect my balance just a bit, and I do go to PT. About a month ago, I saw my podiatrist to see if she had anything to offer for the neuropathy. That was when I learned of Metanx. She gave me a prescription and I have to say that, even though it has only been a few weeks, I am already noticing less symptoms in my feet. I had already tried Gabapentin, Lyrica, Amitryptiline... and none of those really helped. I was on Benfotiamine and R Alpha Lipoic Acid for a year and can't say they really helped. I had my B vitamin levels checked and my B6 was very much in the normal range. B12 was fine, also!
From what I understand, vitamin levels can "look" fine in tests, but some people have problems with the vitamins getting "into" the cells. There are so many variations and each of us is unique.
I will wait a couple of months and check specifically for B6 again, as I am aware of the info on B6 Toxicity. From what I understand, it usually takes several months for Metanx to produce results... My podiatrist said her father took it for years and it seemed to help him. It's pricey. Insurance doesn't cover it and I am paying $65/month. This has been my brief, thus-far experience with Metanx. I'd love to hear from others who have taken it and what their experience has been. So far, I have noticed no negative side effects .... and the early indication seems to be positive as are already feeling a bit better. Best to all... Mike