I was diagnosed with ET with Jak2 by accident 2005. My 1st. Hematologist started me on 500mg. Hydoxyurea 3x daily I was weak nausea and chills just laying around unable Togo to work. I saw the Dr. And told her how I couldn’t tolerate med. she stated have to take this dosage and adjust. Well I never returned to her and found a new hematologist who immediately placed me on 500mg. 1x daily. It worked fine and I have taken it since 2005 and it lowered the platelets enough without an increase in dosage. For some reason since I retired from the dental field in 2020 due to back problems, my platelets dropped enough to discontinue the hydroxyurea. To not take it with high counts can risk stroke heart attack due to possible blood clots.