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Undecided choice of drugs for Osteoporosis

Osteoporosis & Bone Health | Last Active: Sep 8 8:12am | Replies (393)

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@gently

'theofficefan55,
Evenity is the same class of drug as Prolia a monoclonal antibody . These two drugs work in opposite ways. Evenity works to build bone, while Prolia supresses bone loss. Prolia suppresses the cells that break bone down. The scary side of Prolia is that when you stop the drug all the precurser bone-breaking cells that have been collecting mature. Rebound vengence on your bones can be quickly devastating.
You don't mention why you want to quit Prolia. Some endocrinologists would advise that you stay on it. My own impulse would be to switch. The excerpt below would have me choosing Evenity.
"The effect of transitioning to [Evenity] romosozumab after [Prolia] denosumab was evaluated in a phase two study of
romosozumab [35]. When administered after denosumab in postmenopausal women with low BMD, romosozumab increased BMD in the lumbar spine by 2.3% and maintained BMD in the hip, although the increase was of a smaller magnitude than that observed in treatment-naïve patients [35]. While the results of this study suggest that romosozumab may offset the rebound increase in bone resorption observed after denosumab discontinuation, more data are needed to determine whether patients will benefit from transitioning from denosumab to romosozumab. https://www.e-enm.org/journal/view.php?doi=10.3803/EnM.2021.1369
I have a bias against drugs the suppress remodeling which is the action of Prolia and the bisphosphonates. So this would be an easy decision for me.
After Evenity another round of Forteo?
Best luck with your decision.

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Replies to "'theofficefan55, Evenity is the same class of drug as Prolia a monoclonal antibody . These two..."

Thank you, for your reply. I would like to stop Prolia because I wonder if I will remain "stable" as far as my bone health, and maybe I would like to try for "improvement".

I'm leery of Evenity for the warnings of possible stroke or heart attack. My endocrinologist explained the studies for Evenity showed a very slight increase in numbers in people who had a stroke or heart attack vs. people who weren't taking Evenity. I was diagnosed with AFib last February (after I got off the treadmill for my Stress/ECHO test). I asked my cardiologist for his opinion on Evenity, he explained that he wasn't up to speed on Evenity.

I don't believe I can take Forteo again.