I have been on low dose Hydroxy for 2 months now - do notice small mouth sores. Otherwise, just fatigue that is mostly manageable. I have JAK2 mutation with Polycythemia Vera... also have had Chronic Lymphocytic Leukaemia for about 15 years ( with little treatment) and was put on Xarelto and ASA low dose for peripheral artery disease. I am 80 years old, and try to keep active with yoga and core classes as well as a good walk once a day. One Phlobotomy, and platelet count has gone down to 400 range from over 600.