I was on the clinical trial for Aficamten. Double blind study. It didn't agree with me either. Little did I know that both Mavacamten and Aficamten were both "cardiac myosin inhibitors". They first put me on only metoprolol for the beginning of trial and I was fine...when they switched me over to Aficamten...I got so sick on day 2. Remember everyone is different. It has helped alot of people. I wound up being home bound for 4 months...even after stopping the drug. It is a chance you take when you do a clinical study. All is good now...back on metoprolol. No more clinical trials for me. But you don't know unless you try. My advice is to try anything that might give you a good quality of life. Sometimes it works...sometimes it doesn't. ;-(