Same here. After last Prolia shot within six months my GFR went from 59 to 43. I was taking Prolia for six years twice a year. Also ibuprofen had an effect. When I stopped ibuprofen for one month my kidney function went back to 58. But my pain management doctor told me Prolia interferes with kidney function. Something to do with phosphates. I’m going to stop Prolia. They say stop gradually but how does one do that when taking it every six months? I still have questions.