My typically low b.p. decreased to 70s over 50s on average while on Camzyos plus I inexplicably lost 20 pounds. There were other factors like overreplacement of thyroid meds that wasn't discovered until much later that may have contributed to the negative changes that I experienced the last several months prior to stopping Camzyos. Unfortunately I have experienced no improvement in b.p. or weight since stopping in July. In fact I am now in stage 4 heart failure and also have many struggles with activities of daily living. Basically bed ridden. My cardiologist also doubts Camzyos was the culprit. Camzyos made me feel better for many months but never showed a positive effect on ECHOs. Perhaps my longstanding HOCM was destined to progress regardless of what medication I was taking. Will never know. I declined surgery due to potential complications like cognitive decline, conduction problems, anxiety, depression, none uncommon after septal myectomy.