You have to take Pyridoxal 5 phosphate(active b6). This is the active version of b6, it is safe in large doses unlike inactive form pyridoxine. Active and inactive both work against each other in the body. Large amounts of pyridoxine will actually make you more deficient in b6 even though it shows up in your blood stream, you have to check your blood CELL. Half the population cannot convert pyridoxine into the active form Pyridoxal 5 Phosphate that goes into the cell. Unable to convert pyridoxine, it builds up in your system. The more active form you take the more it lowers the inactive form. I had every symptom of b6 deficiency which is also the same as the b6 toxicity and I landed myself in and out of the hospital. No one knew what was wrong with me. After learning this I took fully active forms of b vitamins including extra active b6 and each day I took it I got progressively better, I went from being bed bound and having seizures , swollen thyroid nausea every symptoms to feeling amazing after taking the active form. Before this My blood showed I was high in b6 in my blood stream but it wasn’t making its way into the cell, which is where genes come into play because if you have the MTHFR gene you don’t have the enzyme to convert inactive to active form. Causing deficiency or toxicity. Half the population has this gene. It’s hard to find a fully activated b complex but Klair Labs has one you can find on Amazon. Magnesium is needed to activate b vitamins. Glycinate is a good one. Hope this helps