Only if the bacteria is one of the more rare ones like M. ascessus or M. kliebsella.
The determining factor in which drugs to use is the "susceptibility testing" done in the lab after the culture grows.
You can learn about that here:
https://connect.mayoclinic.org/discussion/resources-for-the-abcs-on-bronchiectasis-and-mac-ntm/?pg=3#comment-962706
Sue

Your treatment is more likely to change based on your tolerance to the drugs, the severity and if your sputum cultures clear by 6 months