Here's my clinical history...

As I've said before, if you come off treatment, have decision criteria to do so.

Once you do, actively monitor through labs and consults while off treatment.

Have decision criteria to go back on.

Our decision criteria to go back on treatment after triplet therapy ended in May 18 with the last 90 day Lupron shot was three or more consecutive increases, 2-4 months apart, PSA between .5-1.0 and imaging. That decision criteria was met in March this year, roughly 4-1/2 years off treatment.

Our treatment plan was SBRT and 12 months Orgovyx, with Xtandi if needed. My PSA at six weeks dropped significant, and three months to undetectable. T went from 600+ to < 9. Given that clinical data, oncologist and I felt no need to add Xtandi. We'll do labs and consults at the end of January and again in April next year. If PSA remains undetectable and T castrate, we'll stop treatment in April and actively monitor, probably same decision criteria,

My T did recover as you can see from my chart, 135, then 400+ and finally at 600+ just before we went back on treatment. Why, I don't know. I do exercise quite a lot, may have been a factor.

Kevin