I have had Sjogren's for a good 40 years, I have tried everything there is to try but finally after all this time found a doctor in Frisco TX that has my eyes much, much better. She started me on Xiidra 4 months ago. I use regular eye drops first, then 10 min later put one drop of Xiidra in each eye. Immediately close my eyes for about 3 min. Then get ready for bed. At bedtime I rub tiny amount of preservative free ointment in my eyelashes. This keeps the Genteal Night-time Gel from crusting in my eyelashes overnight. I then apply a liberal amount of gel in each eye. Close my eye and gently wipe excess off. I then go to bed and I do not open my eyes until morning. Then I gently wash each eye rubbing the gel out of eyelashes then pat dry. When your eyes are as dry as ours, never rub you eyes.