I appreciate your post greatly; as that video gave me the most information (more than three docs and two radiation oncologists); only one of which would even acknowledge the topic of 'drug holidays' or intermittent. In my case I've had a pacemaker installed and probably didn't need it, as the irregular heartbeat (bracycardia) might have been triggered by too long ADT.

I was on Orgo. for 15 months and never was it mentioned as a 'course of treatment you stop' at a point or IF there are side effects. I had many of the side effects and stopped taking it on my own and almost all normalized. BUT, the PSA popped back up so starting it again and we'll test in 3 months.. even another PET scan. Due to cardio-drugs I didn't think brain fog was a factor, but now that you mention it, maybe I can attribute the 'fog' to the ADT treatment not Blood Pressure treatment or statins.

I knew about the re-loading to restart and followed that (thanks); but mostly for that video; 2 years old and far more informative than any information I've encountered on this topic. Cheers and good luck to you too!