Hi PAM: I hope you get to a PCR test of 0.000 soon, but I know people who have not made it to undetected, and they are still doing great. The invention of these TKI drugs, and the fact that we have a few choices of which one works better is a blessing. I was in the clinical trial for Gleevec back in 2000, and I did reach my undetectable status of 0.000 in 2002. I did not stop my Gleevec, and continued to take it until 2018 where it was giving me issues. My doctor told me to stop, and I would be monitored regularly with the intent that if my numbers were to start changing that I would be put on Tasigna. He does not feel I am a good candidate for the Sprycel due to possible pulmonary edema etc. I get my test in Feb, and if I am still undetected it will be 6 years of treatment free remission (TFR). My husband was so concerned about taking care of me all these years and I lost him to Esophageal Cancer in 2019. We just have to stay positive, and keep doing what we are doing. The research continues to find a cure, and that should encourage all of us with CML and other Cancer's Have a good day, because it is.