@pasca I appreciated your post on Auvelity. I hope you will find this encouraging; I've been on it for about 10 months now, with very few side effects, and it seems to be working better than anything I've tried for the last 10+ years. That's not to say that I haven't had some bad days, but like you, being treatment resistant, I've found it pretty amazing to help as much as it has. I was interested to know about your experience with Sprovato. I was on the verge of trying it when I found out about the Auvelity. I opted to go with it just because it was much easier to take. Let me know how you're doing. I hope it is helpful! I know how hard life can be when you feel like there is nothing left to try. I'll be keeping fingers crossed for you! Take care! Here's to both of us getting much better!