My cardiologist is somewhat familiar with Nattokinase. He says the biggest drawback is the lack of studies and because of that he can’t actually recommend taking it but since it’s not a pharmaceutical studies may be hard to come by and will not be funded . From what I have read it has no side effects and does not need an antidote. I was told that my risk of stroke is 3 1/2 - 4% if I do nothing. If I take Eliquis it will be reduced to around 1 1/2%. I am somewhat perplexed by one post in which someone mentioned having had irregular heart rhythm since birth yet apparently had not had any blood clots or strokes even though they had not been on blood thinners all their life. And one other question I have is since there are no blood tests done if you are on Eliquis how do you know it is doing it’s job of preventing blood clots? Is there a test in which it is determined that your blood is not at risk of undue clotting?