Good evening @hillclan, nice to meet you. I am happy to share my Alendronate story with you. After two years on Tymlos.....building bone and being free of any side effects, my endocrinologist told me I had to go on Prolia. That was not a good idea and after a year I was suffering with jaw pain and other side effects. With the support of my PCP, I found a new endocrinologist at Mayo Clinic. He reviewed all of my medical history and recommended Alendronate. Instead of a twice-a-year infusion of Prolia which had a long half-life, the Fosamax is a tablet that I take every Monday morning. I follow the directions carefully and then begin my week.

It has been 18 months now and I have had no issues, discomfort, or side effects. In June of 2024, I will discover how well my bones have held onto the development I received from two years on Tymlos. The Dexa scans will reveal what I am anxious to see.

It seems that my body can handle daily Tymlos injections and weekly Alendronate tablets. It just can't handle large infusions of any medication.

So...positive is exactly how I am feeling. And may you also be safe, protected, and free of inner and outer harm.

Chris

@hillclan I assume you have not yet done any meds? Primary care docs tend to prescribe anti-resorptives like Fosamax or Prolia first. The problem is, my docs, my reading and various studies show that the bone building drugs Forteo, Tymlos or Evenity should be done first, before Fosamax/alendronate. In fact, bone builders have been shown to be less effective if done after Fosamax or Prolia. The problem is that insurance companies require that we fail the antiresorptives first before approving bone builders. If your DEXA results are severe perhaps your doc can advocate for you.

See Ben Leder MD's video online about Sequencing and Combinations and Dr. Keith MCCormick's book Great Bones for more info!

@hillclan I would echo what windy shores is telling you!!! Good luck to you