Hello. I am 70 and have been on some form of HRT since early menopause at 42. Currently I use CombiPatch and plan to stay on it for life. As for my bones, I was diagnosed with Osteopenia in my 40s and just recently Osteoporosis, with the lowest score -2.5 in right femoral hip. Since switching from oral to transdermal a liver enzyme that had been creeping up fell to normal and my cholesterol levels improved. Good luck.