@xplantguy1212 I too was a brittle Type 1 diabetic and had started developing complications of diabetes when I had a pancreas transplant. I was diagnosed in 1975 at age 18. I was transplanted in 2005 at age 48. One of the complications of diabetes is gastroparesis. It is an autonomic neuropathy that affects your stomach. It is a digestive issue caused by your stomach not moving food through your gastrointestinal system. It can cause stomach upsets, nausea, cramping pain, alternating constipation then diarrhea and vomiting. Was gastroparesis considered when you had your stomach issues?

The prednisone I took was a temporary medication to treat pneumonia. It caused a terrible spike in blood sugars at the time. It was not used as one of my immune suppression meds post transplant.

I was on Mycophenolate (Cellcept) and Tacrolimus (Prograf). Eventually the Cellcept was changed to Sirolimus (Rapamune). The transplant center I went to had a protocol to avoid steroids for immune suppression. But that was 18 years ago.

All meds have side effects. It is important to know what they are and also to be aware of potential interactions that may occur with other medications you may be taking. This is especially true when it is a lifelong med like immune suppression. When you are starting a med read everything you can; ask your Dr. questions, or a pharmacist can be helpful. Sometimes they have more time.

I remember that increases in blood pressure and blood sugar were two of the side effects of Tacrolimus. I think I briefly experienced that, but I quickly adjusted to it and numbers returned to normal with some tweaking of the dose. It was a long time ago (18 years). Besides I have prescriptions for blood pressure meds.

I don’t recall any muscle or joint pain associated with medications. I have a bit of those symptoms anyways but I attribute it to being old. I’m pushing 67 now. 😏