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@gamaryanne

Great detail and information here. Thank you all! I would add only one post note.
It seems logical to change chemotherapy treatments before your body has built a complete resistance to one. I initially did Fulfurinox and had great results so why not do it again when my recurrence appeared? I certainly posed that question. They switched me to Gemzar and it has worked too. Keeping the big F in our back pocket I suppose.

Studies are pointing to the effectiveness of Gemzar every other week. I tried to do the 1,8,15 regimen but my platelets would not hold up.

Every other week strategy brought my numbers to normal and opened a window for surgery.

Lastly, my oncologist has mentioned a drug Omnivide. My post surgery visit is today. I am looking deeply for KRAS G12D trials but am anxious to hear their recommendations for next steps.

Enjoy these beautiful Fall days ya’ll. Vitamin D is good for all of us!

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Replies to "Great detail and information here. Thank you all! I would add only one post note. It..."

I hadn't heard of that medication, so I googled it. The brand name is Onivyde, and it's a form of irinotecan. It's used in patients whose cancer has spread and who have already had gemcitabine. Onivyde is dosed with 5FU (fluorouracil) and leucovorin. (I don't know how it's administered, but I'm guessing infusion. I assume the 5FU would be administered via the 46-hour take-home pump.) I'm no medical professional, but to me it sounds like a version of Folfirinox minus the oxaliplatin. So I'm curious what the advantage is versus the standard Folfiri (minus the oxali). I'm not a candidate for the drug yet, but I will make a note of it and ask my oncologist. I'm interested to hear what you learn as well. Thanks for mentioning it!
https://www.onivyde.com/en-us/for-patients