I started with 300 at night and gradually moved to 900mg over time. Been doing this for over a year and my neurologist is happy with how it is working for me. I find I am functional at100mg in the morning with the addition of Tylenol and lidocaine rub on my knees. I have arthritis everywhere as well as fibro and other things so I try stuff periodically. I also find that CBD rub helps with muscle pain and my knees as well. I have a heating pad shaped to my neck and shoulders I got from Amazon that is amazingly helpful.