My observation is that my IgA has gone up each time (from 526 in Feb, 542 in April and last week 557) my Serum Kappa is also increasing as is my K/L Ratio. I have multiple autoimmune triggered conditions (Sarcoidosis, Osteo Arthritis, Peripheral Neuropathy, muscle atrophy, bilateral fasciculations, exocrine pancreatic insufficiencies and I am looking at this picture and wondering if it could be paraneoplastic syndrome with MGUS. When do I need to come back for further exploration and what difference would it make?