Hi Patrick @patrickb76 , welcome to connect. Thank you for your question. The hope is that nerve dysfunction fades away with supplementation sooner than later however each person is different based upon how long they were depleted of B12. In my case I received injections every two weeks for about 6 months then oral supplementation. At the time, my neurologist said it may take up to two to three years for nerves to regenerate. I'd say that was about right for me but again each person's experience varies. My diagnosis was small fiber neuropathy via a skin punch biopsy. Are you experiencing symptoms from B12 deficiency? Have you begun working with a neurologist for treatment?