Hi, Colleen. Awfully good to hear from you. Things are moving along. Thankfully, I realize that about 2x per week now. I seem to keep adding new realities to my catalog every week. But as for the signs, some things just seem to grow on a person. The real toughie right now is Limb Girdle Muscular Dystrophy, type r23. In the last few weeks I have been forced to nearly stop walking because of the pain in all my muscles, including my heart. I am now using about two bottles of nitro per month. The fresh slabs of bone are growing around my head, and, sometimes, my white matter is dark enough I could use it to write a letter to Santa. My multiple myeloma pain is driving me nuts, day and night. Actually, this helps because I have an excuse to not remember things. But that is still a problem as there is only one room for one amnesia case here. I have a roller-walker, so I can still walk a little, maybe a hundred yards or so, before my knees decide to quit bending , as demanded by my LGMD. And I am learning more about my MM almost every day, and my sickle cell impact seems to getting stronger. And I keep telling my wife that my Angelman is just a recognition by God just what sort of person I really am. She tells me that my important word for this time of life is not really "Angelman" but "constipation." Oh, drat!!!!!!!! oldkarl