Hi @kittycatgirl, From personal experience with bone marrow biopsies at Mayo, they do indeed use a mild sedative of propofol and fentanyl for this procedure. You’re out for about 10 minutes and wake up completely relaxed with no memory of what took place. It’s lovely. ☺️
Just make sure you mention you’d like to be under when scheduling the procedure so the anesthesiologist is lined up for the appointment.

If you’d like to be seen at Mayo Clinic, here is a link to their site where you can initiate a request for an appointment.
http://mayocl.in/1mtmR63
Just follow the prompts for a new patient and it will allow you to select Phoenix for your location.

I’ve had 13 biopsies done throughout my treatment with an aggressive form of leukemia. I definitely prefer being out. But when that wasn’t an option at my local hospital for one of them, I was given lorazapam to take ahead of time. The directions were to swallow a .5mg tablet 1 hour before the appt. Then at the half hour mark, take another.
I wasn’t ‘out’ but it did help keep me relaxed throughout the appointment. It might be an option if you need this biopsy in a timely manner and don’t have an appointment with Mayo yet.

Good luck with your biopsy and hopefully you’ll be able to find a local clinic who will be able to offer you a twilight sleep.
We have quite a few members who also have Polycythemia Vera in our Blood Cancer and Disorders group and we’re all here to support you if you have any questions or concerns.
Will you let us know what you find out?