HI lucyjake, That is exactly what I do--take half-dose daily (ie., one 5 mg Eliquis instead of two), and take an extra Eliquis if I am in an AF episode--also because on full dose (2 pills), I was bleeding too much (nose, cuts, etc.) and I have an inflammatory bowel disease history w/ a lot of bleeding in past. I have paroxysmal AF with digestion/vagus nerve-related triggers. One cardiologist suggested I cut the 5 mg Eliquis in half and take 2.5 mg morning and 2.5 at night, as it doesn't stay in the bloodstream very long, but since almost all of my episodes are at night, I take a 5 mg Eliquis each night. Like you, I have low BP, no structural heart defects, and I take various supplements that tend to have some of the same effect as Eliquis. There is evidence that "blood thinners" taken 24/7 have other negative effects on our bodies, which you never hear from cardiologists. Many things affect one's actual numerical stroke risk, and the oft-quoted "5 times higher risk w/ AF" is misleading and inaccurate. All best wishes!