Ultimately yes, after being on Cellcept for 18 years (originally at 500mg. twice a day and then for the last 8 years of it on 250mg. twice daily, I was switched to Myfortic 180mg. twice daily. for the last 5 months. But it wasn't just the gastrointestinal issues....it was chronic, rotten diarrhea which eventually caused a total rectal prolapse and a tear along the uterine wall. This was all surgically repaired 2 months ago and things are so much better...and I don't seem to be having any issues (so far) with the Myfortic.