5 weeks into Amikacin iv I had extreme dizziness, got sent to ER, Dr cut dosage some but dizziness continued for 7 more weeks. Once stopped it went away, thankfully. Arikayce was ok at first weeks with daily usage, after 4 weeks it was ear problems extreme cough, sore ribs, headaches. At 4 1/2 months I could not neb for more than 7-10 minutes and Dr then stopped treatment. Continued requests to Arikares, Insmed and Kroger went unanswered. Now the standard practice maybe nebbing 3 times per week. I may have tolerated hat regime, I'll never know. It does work for many folks.