Sorry to read all that you are going through.... and I hope this comment isn't taken as a flimsy offhand response (I too have a laundry list of health issues) and this is from a column appearing in the newspaper we used to get... not sure if USA and Canada it was called Dr.Gott, I think he has passed away now. He had heard from readers with RLS that put an unwrapped bar of soap in their bed under the bottom of the sheet and for some reason it helped many readers! Years ago didn't have Internet to check these things but years later people are still saying it helps them and others saying its simply not proven to help. I just read these and this response from experience with husband from leg cramps and honestly he didnt even want to try but he has not had them since our putting the soap in and in fact one day I changed his sheets to launder and bar must have fallen on floor other side of bed I didnt see it.. the next morning he said oh he had cramp back - later when making be discovered soap missing, put it back and hasnt had since. Am sure a quick internet search MIGHT give some information and I hope it's ok to mention this considering what you are going through and the medications and other health issues but just thought would mention and has anyone else ever heard of this or tried it? J.