After discovering that my blood platelets were too low for surgery, I was referred to a hematologist who ordered a bone marrow biopsy to confirm ITP. In addition, it was found that I also have Cold Agglutin Disease and MGUS. Various treatments were tried for the ITP and Nplate was found to work best. Over 4 years my platelet count went from 9 to over 200 and has remained in the 150 to 170 ranged. Before every Nplate infusion I have blood draw for a CBC and a Citrate count. The Citrate count is used because the CBC tube can cause my platelets to clump and result in a lower or 0 count. Over the last year of CBC draws I have noticed that the Lymphocyte Automated component has been lower than the standard range. Of the 22 CBC's this past year 18 have indicated a low Lymphocyte Automated component. The previous year I had 35 CBC's and of those only 5 had a low Lymphocyte Automated component. I've been told that ITP, CAD and MGUS are autoimmune conditions. I'm wondering if the 85% of CBC's with low lymphocytes this past year, compared with only 5% of the previous year, could be an indication that my immune system is now targeting this component of the CBC. My hematologist has never addressed this issue with me and am wondering if this issue is not significant or am I overly concerned. Anyone with autoimmune blood conditions seeing similar lymphocyte automated results?