1. < Polymyalgia Rheumatica (PMR)

A vaccine for PMR?

Posted by pkalkstein @pkalkstein, Sep 22, 2023

This sounds almost too good to be true. But if it works for these other diseases, it might work for PMR, too.
https://www.thehealthsite.com/diseases-conditions/autoimmune-disorder-treatment-new-vaccine-may-completely-reverse-diseases-1009841/

Interested in more discussions like this? Go to the Polymyalgia Rheumatica (PMR) Support Group.

krueg | @krueg | Sep 22, 2023

Wow that would be fantastic. Lets hope for the best of these trials.

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1sunny | @1sunny | Sep 23, 2023

Would there not be a definitive test for a virus associated with PMR if vaccine was possible. All I have had or read about with testing is SED rate (and the other common one, and nothing anywhere about specific virus, which is what triggers many diseases, and is used to develop vaccines for those specific diseases.

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1 reply
pkalkstein | @pkalkstein | Sep 23, 2023
In reply to @1sunny "Would there not be a definitive test for a virus associated with PMR if vaccine was..." + (show)
@1sunny

Would there not be a definitive test for a virus associated with PMR if vaccine was possible. All I have had or read about with testing is SED rate (and the other common one, and nothing anywhere about specific virus, which is what triggers many diseases, and is used to develop vaccines for those specific diseases.

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Vaccines do generally have specific targets. And no one knows where the the PMR target is. But this apparently is not a vaccine in the usual meaning. "However, the inverse vaccine is different from the typical vaccine. It job is to remove the immune systems memory of one molecule. This is how it can stop autoimmune disorders."

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1 reply
nyxygirl | @nyxygirl | Sep 23, 2023

this company is right here in my backyard - Cambridge MA . https://www.linkedin.com/company/anokion-sa/about/. The technology comes from Jeffrey Hubbell, PhD's Lab Co-founder, Chief Scientific Advisor
VERY RECENT ( sept 2023) news:
https://news.uchicago.edu/story/inverse-vaccine-shows-potential-treat-multiple-sclerosis-other-autoimmune-diseases
This Italian group is keen on defining PMR on the spectrum of auto inflammatory vs autoimmune- contrast this to MS, e.g., where the target of destruction is myelin basic protein .
I would suggest that PMR is not going to be treated by inverse -vaccines any time soon.

"Immune system activation in polymyalgia rheumatica: Which balance between autoinflammation and autoimmunity? A systematic review
Authors lElvis Hysa a, Emanuele Gotelli a, Silvia Sammorì a, Marco Amedeo Cimmino a, Sabrina Paolino a, Carmen Pizzorni a, Alberto Sulli a, Vanessa Smith b, Maurizio Cutolo "

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teddyz | @teddyz | Sep 24, 2023
In reply to @pkalkstein "Vaccines do generally have specific targets. And no one knows where the the PMR target is...." + (show)
@pkalkstein

Vaccines do generally have specific targets. And no one knows where the the PMR target is. But this apparently is not a vaccine in the usual meaning. "However, the inverse vaccine is different from the typical vaccine. It job is to remove the immune systems memory of one molecule. This is how it can stop autoimmune disorders."

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PMR may be farther down the list of autoimmune disorders that they target but I think it's an exciting possibility. If they can end MS, just think what a revolution that would be for the thinking about all autoimmune diseases!

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1 reply
krueg | @krueg | Sep 26, 2023
In reply to @teddyz "PMR may be farther down the list of autoimmune disorders that they target but I think..." + (show)
@teddyz

PMR may be farther down the list of autoimmune disorders that they target but I think it's an exciting possibility. If they can end MS, just think what a revolution that would be for the thinking about all autoimmune diseases!

Jump to this post

I totally agree. The fact that this vaccine is out there is a real break thru. Lets hope for the future!!!

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